When injury to the brain occurs, such as in Traumatic Brain Injury (TBI), one will experience symptoms associated with the area of the brain that was damaged. The neurological damage of the brain can cause acute and/or chronic damage to brain function, physical impairments, as well as cognitive and emotional disorders.
Mild traumatic brain injury may not require more than medication and frequent monitoring, but those with a more severe injury face a longer recovery and rehabilitation time frame. Today, treatments may include medication, surgery, and/or physical therapy. Unfortunately, there is no claimed cure that will prevent nerve damage or promote nerve healing, but scientists are studying the potential attributes of mesenchymal stem cells (MSCs) for TBI.
Mesenchymal Stem Cell Therapy for Traumatic Brain Injury
Mesenchymal Stem Cells (MSCs), are adult stem cells that have the ability to differentiate into multiple other cells types in the body. They are multipotent and have broad anti-inflammatory and immune-modulatory properties. MSCs can be derived from various tissue sources; adipose (fat) tissue, umbilical cord tissue (Wharton’s jelly), and bone marrow tissue.
Mesenchymal stem cells have been found to be potentially therapeutic in many regenerative medicine studies for the central nervous system. They have become an interesting topic due to their natural paracrine effect in which they secrete cytokines, chemokines, growth factors, and extracellular vesicles.
In a recent review in the journal, Pharmaceuticals, researchers discuss the benefits of MSCs, their secretome, and their regenerative effects on those with Traumatic Brain Injury. The immunomodulatory properties of MSCs show to help modulate the secondary injury mechanisms of TBI, help control the inflammatory response, and promote neural stem cell proliferation and differentiation. The extracellular vesicles, also known as exosomes, secreted by MSCs show to reduce neuroinflammation and promote neurogenesis and angiogenesis.
Mesenchymal Stem Cells have received considerable attention as a potential therapy for TBI. Further studies and research are needed but the initial indications of safety and potential has been promising.
This post was written by Becky Palmer, a medical professional at Stemedix Inc. At Stemedix we provide access to Regenerative Medicine for traumatic brain injury, also known as stem cell therapy for traumatic brain injury. Regenerative medicine has the natural potential to help improve symptoms sometimes lost from the progression of many conditions.