Ipamorelin and Sermorelin are two hormones that may be given individually or in combination. Both are growth hormone-releasing peptides (GHRPs), which are also known as human growth hormone-releasing hormones (GHRH) or growth hormone-releasing factors (GHRF).
Sermorelin and Ipamorelin are both used to treat adult subjects with growth hormone shortages by increasing the synthesis and release of HGH, either together or separately.
In certain individuals, GHRFs such as Sermorelin and Ipamorelin have been shown to be superior to direct growth hormone injections because they induce the body to produce growth hormone in a manner that is more consistent with normal physiological processes.
Throughout the day, growth hormone is produced in spurts or pulses. Sleep, healing, exercise recovery, and cellular regeneration are all aided by these pulses, which peak in the evening. According to current research, the reduction in human growth hormone (HGH) levels in the blood as we age is due to fewer “pulses” rather than a decrease in HGH synthesis.
Sermorelin and Ipamorelin are growth hormone-releasing peptides that stimulate pituitary receptors to release HGH, resulting in a more “natural” rise in HGH levels.
Sermorelin vs. Ipamorelin: What’s the Difference?
Sermorelin and Ipamorelin are chemically extremely similar. They’re both long-chain peptides that vary mostly in the quantity and composition of amino acids in their chains.
Sermorelin and Ipamorelin are man-made (synthetic) forms of Ghrelin, a GHRH that promotes the synthesis and release of HGH and is naturally generated by your body. These peptides, for example, are large-chain growth hormone-releasing peptides that vary only in the number of amino acids in the peptide chain.
The substances are medicines that are designed to mimic the effects of Ghrelin. Ghrelin, like ipamorelin and sermorelin, is a 28-amino-acid peptide that increases growth hormone production.
Ipamorelin and sermorelin both increase human growth hormone production with little, if any, unfavorable side effects. Because they only vary in the size of their individual amino acid chains, they engage with distinct receptor locations in the brain and pituitary.
Both have been shown to be successful in treating people with low-level GHD when used alone. According to current studies, there may be some advantages to combining the two treatments since they affect distinct receptor sites in distinct ways.
What Are the Benefits of Sermorelin/Ipamorelin Therapy in Combination?
When combined with another GHRH, such as ipamorelin, sermorelin has been found to be helpful in treating age-related growth hormone decrease. Sermorelin has been proven to generate a longer-lasting and more effective HGH pulse when coupled with a pre-determined dosage of ipamorelin.
Sermorelin and ipamorelin, when taken together, produce a synergistic release of HGH from the pituitary gland, according to recent research.
The most appropriate candidates for combination sermorelin/ipamorelin therapy are those who show symptoms of aging and have both low HGH and low IGF-1 levels. Sermorelin/ipamorelin treatment has been found to increase growth hormone levels as well as insulin-like growth factor-1 (IGF-1), which aids in:
- Increase the density of your bones
- Reduce cardiovascular risks and improve heart health
- Increase your strength and lean muscle mass.
- Enhance your fat-burning abilities.
- Weight loss should be encouraged.
- Improve your sexual performance and libido (erectile dysfunction).
- Boost your energy and stamina by strengthening your immune system.
- Improved sleep leads to improved cognition and memory, as well as improved bone health and fracture repair.
If you are a licensed researcher, you can only buy Sermorelin & Ipamorelin with a doctor’s prescription and are administered as injectable treatment, either alone or jointly in lab subjects.